What is FOXO4-DRI?
Research Focus: Longevity
FOXO4-DRI (D-Retro-Inverso) is a synthetic peptide designed to selectively induce apoptosis (programmed cell death) in senescent cells (zombie cells). It is a key compound in senolytic research.
At a Glance
Senescent cells accumulate with age and secrete inflammatory factors that damage surrounding healthy tissue. FOXO4-DRI works by disrupting the interaction between the FOXO4 protein and p53, a pathway that keeps senescent cells alive. This section provides a general overview of its research context.
About FOXO4-DRI
Senescent cells accumulate with age and secrete inflammatory factors that damage surrounding healthy tissue. FOXO4-DRI works by disrupting the interaction between the FOXO4 protein and p53, a pathway that keeps senescent cells alive.
How It Works
Senolytic Action
Selectively targets and eliminates senescent cells, reducing the burden of 'zombie cells' in tissues.
p53 Pathway Disruption
Interferes with the FOXO4-p53 interaction, triggering apoptosis in senescent cells.
Current Research Insights
Senescence Clearing
FOXO4-DRI is highly regarded in anti-aging research for its potential to clear out damaged cells, leading to tissue rejuvenation and improved function.
Areas of Study
Anti-Aging and Rejuvenation
Investigated for reversing age-related decline and improving organ function.
Age-Related Diseases
Studied for its potential role in conditions like kidney failure and hair loss linked to senescence.
FOXO4-DRI is strictly intended for laboratory and clinical research:
- Available exclusively from authorized research suppliers
- Not FDA-approved for general therapeutic use
- Comprehensive safety, efficacy, and dosage guidelines remain under ongoing investigation
FAQs
Research
- Studies on senolytics and their mechanism of action, particularly the FOXO4-p53 pathway.
- Research into the effects of senescent cell clearance on tissue health.
(The above references are representative and support the research context of this peptide, GLP hormone or regenerative therapy. All claims are for research purposes only and do not imply approved medical use.)